منابع مشابه
Naturally derived anti-HIV agents.
The urgent need for new anti-HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti-HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the therapeutic usefulness of the various reverse transcripta...
متن کاملDesigning a Nanotube Using Naturally Occurring Protein Building Blocks
Here our goal is to carry out nanotube design using naturally occurring protein building blocks. Inspection of the protein structural database reveals the richness of the conformations of proteins, their parts, and their chemistry. Given target functional protein nanotube geometry, our strategy involves scanning a library of candidate building blocks, combinatorially assembling them into the sh...
متن کاملThe paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
The DDK syndrome is an early embryonic lethal phenotype observed in crosses between females of the DDK inbred mouse strain and many non-DDK males. Lethality results from an incompatibility between a maternal DDK factor and a non-DDK paternal gene, both of which have been mapped to the Ovum mutant (Om) locus on mouse chromosome 11. Here we define a 465-kb candidate interval for the paternal gene...
متن کاملMacrophage Activation and Differentiation Signals Regulate Schlafen-4 Gene Expression: Evidence for Schlafen-4 as a Modulator of Myelopoiesis
BACKGROUND The ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in macrophages, which are key cellular regulators of innate immunity. METHODOLOGY/PRINCIPAL FINDINGS Multiple members of the Slfn f...
متن کاملISSCC 2006 / SESSION 11 / RF BUILDING BLOCKS AND PLLS / 11 . 8 11 . 8 Electrical Funnel : A Broadband Signal Combining Method
Recently, there has been growing interest in using silicon-based integrated circuits at high microwave and millimeter-wave frequencies. The high level of integration offered by silicon enables numerous new topologies and architectures for low-cost reliable SoC applications at microwave and millimeter-wave bands, such as broadband wireless access (e.g., WiMax), vehicular radars at 24GHz and 77GH...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2012
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2012.188